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a patient today asked about negative symptoms in schizophrenia negative symptoms refer to symptoms or a lack basically of normal qualities that an individual typically would have without the schizophrenia illness and as schizophrenia progresses these negative symptoms tend to get worse negative symptoms are believed to be a cause of hypoactivity of dopamine in the mesocortical pathway of the limbic system so the positive symptoms which have also been discussed elsewhere positive symptoms are things like hallucinations and delusions those are from hyperactivity of dopamine in the mesolimbic pathway however likely due to a feedback mechanism in the schizophrenic brain because thereamp;#39;s a hyperactivity of dopamine in the mesolympic pathway you get a hypoactivity of dopamine activity in the mesocortical pathway of the brain and that results in some of these negative symptoms and to give you some examples of these negative symptoms individuals with schizophrenia May over time develop
