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well good afternoon everybody and welcome to biostatistics in action tips for clinical research a lecture series this series of talks is organized by CTSA in collaboration with department of biostatistics. Our special guest today is Dr. Bruce Levin professor and past chair in the department of biostatistics Dr. Levin has extensive expertise in designing and consulting for clinical trials and today he will present a very interesting study and point out how NOT to conduct a randomized clinical trial without further ado Dr. Levin thank you thanks very much for coming on this hot and humid day. Cody does have printed handouts of my talk so you donamp;#39;t need to take notes if you prefer not to and although I am inclined typically to give technical biostatistical talks I promise you today there wonamp;#39;t be a single formula and this is a non-technical talk nevertheless itamp;#39;s going to raise some subtle issues about the conduct of a randomized controlled trial I want to say that