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Hello friends welcome to am exploration in this video you will learn about empugly flozin also known as Guardians we will go over the mechanism of action indications side effects dose range and much more about Guardians if you are looking for a specific piece of information make sure to check out the chapters section of the video and thats me my name is KK Im a board-certified Internal Medicine physician lets dive in starting with the mechanism of action Guardians is an stlt2 inhibitor sodium glucose co-transporter 2 is a predominant transporter responsible for reabsorption of glucose from the glomerular filtrate back into the circulation Guardians reduces real reabsorption of filtered glucose it also lowers the renal threshold for glucose and increases urinary glucose excretion Guardians reduces sodium reabsorption and increases the delivery of sodium to the distal tubule this may influence physiological functions such as lowering both preload and afterload of the heart and down re