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the overall efficiency of blow fill seal has two notable advantages over a comparable output class filling line first BFS has a smaller footprint of the filler itself and the overall lower footprint of the entire line This is especially notable when considering the net relative output of a BFS line versus a glass filling or pre-filled syringe line of comparable physical size second filling efficiency as determined by net final amount of drug substance that is yielded from a particular batch is on par or better than an equivalent glass line nominal ranges for filling efficiency with BFS are 90 to 95% however there are many design factors of the filling Suites either for glass or FS that can impact these efficiency measurements these include distance of filling vessels from the fillers compounding batch sizes and tank volumes piping arrangements and IPC requirements for the process itself
