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In this 2-minute neuroscience tutorial, the topic of discussion is long-term potentiation (LTP), a process that strengthens synaptic connections between neurons through frequent activation. LTP is believed to facilitate changes in the brain that contribute to learning and memory. The primary mechanism involves the NMDA receptor, a type of glutamate receptor. In NMDA-receptor dependent LTP, glutamate release first activates the AMPA receptor. However, NMDA receptors, located nearby, are typically inactive at low glutamate levels due to a magnesium ion blocking their ion channel. Increased stimulation of AMPA receptors from frequent action potentials leads to depolarization of the postsynaptic neuron, enabling LTP.
