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Dr. Rishi Desai from Osmosis shares three essential tips for taking an effective patient history. While the mechanics involve obtaining the chief complaint, History of Present Illness (HPI), past medical history, medications, allergies, family and social history, and a review of systems, Desai emphasizes the importance of execution. His first tip is to listen well and show empathy, acknowledging that patients choose to speak to a human for a reason, beyond just answering standard questions. This personal approach helps in understanding their concerns better and improving the overall quality of the patient interaction.