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Throughout history, many medical treatments now seem barbaric and cruel, reflecting a limited understanding of human health. Five particularly dangerous practices highlighted include trepanation, a surgical method where a hole is drilled into the skull to expose the brain, believed to cure various ailments by releasing evil spirits. This practice dates back to Neolithic times, with evidence found in cave paintings and ancient burial sites. Individuals exhibiting abnormal behavior were often subjected to this procedure, which was also a common treatment for conditions like seizures and epilepsy.