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human papillomavirus or HPV is the leading cause of cervical cancer to understand how HPV infection leads to the development of abnormal cervical cells and if left untreated to cervical cancer letamp;#39;s first take a look at a healthy cervix the vagina opens to the outermost section of the cervix the active cervix while the three centimeters structure connecting the vagina to the uterus is the endo cervix the transformation zone where the endo cervix joins the acto cervix is the transition between the columnar glandular cells of the endocervical canal and the squamous epithelial cells that line the active cervix the typical side of an HPV infection is the transformation zone of the cervix up to nine out of ten cervical cancers are squamous cell carcinomas these cancers form in the cells of the ecto cervix and the cancer cells have features of squamous cells under the microscope most of the other cancers are ad no carcinomas adenocarcinoma czar distinguished as cancers that develop f