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oday, Dr. Niraj discusses dot blot and slot blot hybridization techniques which are used to identify, quantify, and determine the concentration of DNA, RNA, or proteins in a sample without the need for restriction digestion or electrophoresis. By applying the sample directly to a membrane, specific molecules can be detected without extensive preparation. Dot blot and slot blot techniques are named after the shape in which the sample is loaded onto the membrane.