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about eight to ten percent of patients with metastatic colorectal cancer have a B Rafi 600 a mutation this actually pretends for a very poor prognosis typically the survivals are about half that of b-raf wild-type patients so we need to find other treatment options for these patients with b-raf mutated disease patients with b-raf mutated colorectal cancer donamp;#39;t tend to respond like patients with b-raf mutated melanoma to be raf inhibitors there was really amazing scientific work done that showed that in colon cancer in particular when you give a b-raf inhibitor or you inhibit this pathway you get reflexive up regulation of the EGFR and hip of the EGFR receptor so if we give a combination of an EGFR inhibitor and EGFR antibody plus a b-raf inhibitor or an EGFR inhibitor plus AB uf inhibitor plus or MEK inhibitor to double hit the pathway weamp;#39;ve seen much better efficacy so the beacons study is a study thatamp;#39;s looking at bringing essentially a new standard into pati
