Bind motif in QUOX

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Aug 6th, 2022
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How to bind motif in QUOX

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Hello again, itamp;#39;s Professor Hendrix and iamp;#39;ve got behind me binding sites for the drosophila transcription factor giant. giant is a regulatory transcription factor that is involved in anterior posterior patterning in the early fruit fly embryo. now iamp;#39;ll tell you later where i got these binding sites but when we look at what the motif looks like itamp;#39;s often represented using these sequence logos as you can see here the height of each character corresponds to essentially how frequently that particular character or nucleotide occurs or more precisely it describes the information content of that position of the motif and in this particular representation right here we have our frequency matrix which i introduced previously as a count matrix itamp;#39;s essentially the same thing we can see that some of these positions have for example 54 occurrences of an A at this position which presumably refers to this particular a right here

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Transcription factors are proteins involved in the process of converting, or transcribing, DNA into RNA. Transcription factors include a wide number of proteins, excluding RNA polymerase, that initiate and regulate the transcription of genes.
The common motifs include the helix-turn-helix, the homeodomain, the leucine zipper, the helix-loop-helix, and zinc fingers of several types. The precise amino acid sequence that is folded into a motif determines the particular DNA sequence that is recognized.
Although each of these proteins has unique features, most bind to DNA as homodimers or heterodimers and recognize DNA through one of a small number of structural motifs. The common motifs include the helix-turn-helix, the homeodomain, the leucine zipper, the helix-loop-helix, and zinc fingers of several types.
The Zinc Finger Motif The zinc finger DNA-binding motif is common to many transcription factors in the human genome.
Transcription factor binding motifs (TFBMs) are genomic sequences that specifically bind to transcription factors. The consensus sequence of a TFBM is variable, and there are a number of possible bases at certain positions in the motif, whereas other positions have a fixed base.
A binding motif pair consists of two motifs each derived from one side of the binding protein sequences. The discovery is a directed approach that uses a combination of two data sources: 3-D structures of protein complexes and sequences of interacting proteins.
DNA binding motifs. A region found in a regulatory protein that is capable of binding to a specific base sequence in DNA; a critical part of the proteins DNA-binding domain. ( MAjor grooves) 1 / 57. 1 / 57.

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